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Under homeostatic physiological conditions, activated microglia and astrocytes can produce ROS and nitric oxide (NO) molecules that play roles in defense mechanisms against microbial pathogens

In other words, OS may be considered as a state in which the mechanism for maintaining oxidative and reductive states within the body has failed

10.1016/j.ijbiomac.2023.126388 5

eCLIP reveals NS3 binding to defined RNA elements in viral (+) and () RNA In addition to affecting NS3 and NS5B interaction, we next aimed to analyse whether D1467G impacted the binding of NS3 to HCV RNA